Since 1996, there have been several published clinical studies that report the efficacy of Photobiomodulation for Female Fertility and Reproductive Health. We are delighted to contribute our own case study series (carried out at the Laser Medicine Centre in London) to the growing body of work in the field. Our recently published paper in the Journal of Clinical Medicine, describes The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health (Phypers et al 2024). The paper reports a Prospective Case Series with 9-Month Follow-Up and the clinical study abstract follows:

Photobiomodulation for Female Fertility Clinical Study Abstract

Background/Objectives: Female infertility due to unexpected causes exhibits a great challenge for both clinicians and women who are trying to conceive. The present clinical case series study aimed to evaluate the efficacy of multiple wavelengths of red and near-infrared (NIR) laser photobiomodulation (PBM) for increasing the potential of fertility in women and improving reproductive health in unexplained infertility issues. The objectives were to assess the following: (1) any adverse effects; (2) the possibility of producing an effective PBM protocol; (3) and healthy live birth. The inclusion criteria were to related to females who failed to conceive naturally beyond two years, multiple miscarriages, molar pregnancy, non-viable embryos from in vitro fertilisation (IVF) cycles, and failure to complete successful implantation of viable pre-implantation genetic tested (PGT-A) embryos. Photobiomodulation for Female Fertility Methods: Case series of three female subjects with unexplained age-related infertility issues, which included a failure to conceive naturally beyond two years, multiple miscarriages, molar pregnancy, non-viable embryos from IVF cycles, and failure to complete successful implantation of viable pre-implantation genetic tested (PGT-A) embryos. In each case, previous conditions were recorded and then compared with outcomes after the patient received a course of PBM treatments. In every case, fertility outcomes improved. Three cases resulted in a full-term pregnancy and the birth of a healthy baby. PBM treatments were given at weekly and/or at two-week intervals using IR and NIR wavelengths between 600 nm and 1000 nm in the lead up to natural conception, IVF oocyte retrieval, blastocyst/embryo implantation, and/or the production of viable embryos. Results: In every case, fertility outcomes improved. Improvements in reproductive health outcomes in each case give reason to suggest that PBM may help to improve unexplained age-related infertility. Conclusions: Our study demonstrated that multiwavelength of red and NIR PBM with either an LED or laser, or a combination, improved female fertility and reproductive health and contributed to healthy live births in females diagnosed with unexplained age-related infertility. Extensive studies with robust data are warranted to validate our PBM dosimetry and treatment protocols. Moreover, understanding the genetic and phenotype biomarkers is important to standardise a range of PBM light dosimetry.

At Laser Medicine, we have developed effective Photobiomodulation for Female Fertility protocols for individual patients over the last 10 years. We follow closely therapeutic laser protocols and insight from clinical studies, to provide patients with safe and effective red light therapy for ovarian rejuvenation and sperm quality. We regular see improvements in fertility outcomes for many patients who commit to regular sessions in the lead up to IVF cycles, and for planned natural, spontaneous conception.

Read more about our Photobiomodulation for Female Fertility Therapeutic Laser treatments.

Find out more about the Laser Medicine Ovarian Rejuvenation Programme where we combine Photobiomodulation Laser Therapy with Ovarian PRP for Female Fertility.

Previous notable clinical studies, which explore the efficacy of Photobiomodulation for Female Fertility (and in some cases, male fertility) include:

Ruth Phypers

Ruth Phypers combines extensive health and recovery expertise with Low Level Laser Therapy (Cold Laser / PBM) technology. Ruth Phypers is an expert in therapeutic laser protocols developed over 30 years of extensive research. She runs a Harley Street medical practice in Therapeutic Laser medicine (Low Level Laser Therapy | Photobiomodulation) focusing on general health, fertility, thyroid, pain relief, nerve damage, neurodegenerative disease and youthful ageing.